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Chloe (voice of Drew Barrymore) a diamond-clad, bootie wearing Beverly Hills Chihuahua enjoys her luxurious life so much, she hardly notices Papi (voice of George Lopez), a tough looking Chihuahua who happens to be head-over-paws for the pampered pooch.
But when Chloe gets lost in the rough streets of Mexico with only a street-wise German Sheperd (voice of Andy Garcia) to help her find her way home, Papi heads south of the border -- joining forces with a motley crew: two humans (Piper Perabo, Manolo Cardona), a sly rat (voice of Cheech Marin) and a nervous iguana (voice of Paul Rodriguez) - to rescue his true love.
| Drew Barrymore | Chloe (voice) |
| Andy Garcia | Delgado (voice) |
| George Lopez | Papi (voice) |
| Cheech Marin | Manuel (voice) |
| Paul Rodriguez | Chico (voice) |
| Plácido Domingo | Monte (voice) |
| Edward James Olmos | Diablo (voice) |
| Loretta Devine Delta | (voice) |
| Jamie Lee Curtis | Aunt Viv |
| Luis Guzmán | Chucho (voice) |
| Eddie Piolin | Sotelo Rafa (voice) |
| Carlos Juvera | Tomás (voice) |
| Alex Mendoza | Frightened Terrier / Gang Leader Bull Dog (voice) |
| Lombardo Boyar | Praying Dog |
| Jon Molerio | Fight Mutt #1 / Gang Dog #1 (voice) |
| Margo Reymundo | Carthay Hotel Pekingese (voice) |
| Lisa Marie Quillinan | Carthay Hotel Poodle (voice) |
| Ed Francis Martin | Coyote (voice) (as Ed F. Martin) |
| Grey DeLisle | Mother Dog (voice) |
| Axel Alba | Pedro |
| Pascal Petardi | Train Dog #1 (voice) |
| Piper Perabo | Rachel |
| Manolo Cardona | Sam Cortez |
| Michael Urie | Sebastian |
| José María Yazpik | Vasquez |
| Maury Sterling | Rafferty |
| Jesús Ochoa | Officer Ramirez |
| Eugenio Derbez | Store Owner |
| Omar Leyva | Ranger #1 |
| Naomy Romo | Ranger #2 |
| Ali Hillis | Angela |
| Marguerite Moreau | Blair |
| Nick Zano | Bryan |
| Carmen Vera | Inn Keeper Lady |
| Gina Gallego | Shelter Director |
| Hiram Vilchez | Desk Clerk |
| Alberto Reyes | Bellman |
| Enrique Chavero | Doorman / The Carthay |
| Andres Pardave | Doorman / Baja Sur Hotel |
| Juan Carlos Martín | Armand |
| Juan Antonio Saldaña | Conductor |
| Sal Lopez | Ring Announcer |
| Giovanna Acha Aleman | Museum Guide (as Giovanna Acha) |
| Fernando Manzano | Desk Sergeant |
| Randall England | Butler |
| Claudia Cervantes | Chic owner #2 |
| Lilly Lange | Chic Owner #2 |
| Brandon Keener | Waiter |
| Jack Plotnick | Dog Nanny |
| Mary Paz Mata | Shaman Lady |
| Mayra Serbulo | Poor Woman |
| Montserrat de León | Baja Sur Desk Clerk |
| Bernice Romero | Lady |
| Antonio Infante | Museum Security Guard #1 |
| Tomihuatzi Xelhuantzin | Museum Security Guard #2 |
| Erick Fernando Cañete | Little Boy |
| David Goldsmith | Limo Driver |
| Julie Claire | Claire - Beverly Hills Store Manager |
| Holly Bonelli | Shop Girl |
| Ethynn Tanner Cerney | Beverly Hills Kid |
| Mike Faiola | Josh |
| Mercedes Connor | Beverly Hills Shop Girl (uncredited) |
| Christopher Maleki | Yikes (uncredited) |
March 03, 2009
October 03, 2008
Raja Gosnell
Analisa LaBianco
Jeffrey Bushell
PG
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